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［摘 要］ 目的 评价窄谱UVB治疗寻常性银屑病的疗效及安全性，并与改良
PUVA(PUVA+UVB)疗法比较。
方法 108例患者，其中50例单纯照射窄谱UVB；58例口服8-甲氧补骨脂素片，0.6
mg/kg/次 ，2 h后照射UVA和UVB；每周3次，疗程8周，观察疗效与安全性。
结果 经过8周治疗，窄谱UVB组基愈率为70.0%，显效率为
20.0%。改良PUVA组基愈率为96.6%，显效率为3.4%；不良反应：窄谱UVB组仅个别患者出现轻度红斑、色素沉着及皮肤瘙痒。改良PUVA组发生率为40.3%，多为轻中度消化道反应及皮肤瘙痒、色素沉着等。照射时间窄谱UVB组最长不超过7
min，改良PUVA组最长需30 min以上。
结论 窄谱UVB治疗寻常性斑块型银屑病具有良好疗效，与改良PUVA疗法相比，虽然疗效略逊，但方法简便，患者无需服药，照光时间短，不良反应发生率亦低。
［关键词］ 窄谱UVB疗法；改良PUVA疗法；银屑病
［中图分类号］ R 758.63
［文献标识码］
B
［文章编号］ 1001-7089(2005)03-0151-03
Clinical
Trail of NarrowBand UVB on Treating Psoriasis
Vulgaris
YANG
Haizhen,WANG Ke,DUAN Zhouying，et
al
(Department
of Dermatology,the First Hospital of Beijing University,Beijing 10010，China)
Abstract:
Objective
To evaluate the efficacy and safety of NB-UVB，
in comparison with modified PUVA(PUVA+UVB) in patients with vulgar
psoriasis.
Methods
108 patients affected by vulgar chronic plaque psoriasis，of
which 50 subjects were only radiated with narrowband
UVB，and 58 subjects were orally administered with
8-MOP，0.6 mg/kg body
weight.2 hours later radiated with UVA and UVB. All subjects were radiated 3
times per week，with 8week
treatment duration.
Results
After 8-week treatment course，the
basically effective rate in narrowband group was
70%， and the significantly effective rate was
20%.Where in the modified PUVA group，the basically
effective rate was 96.6%，and the significantly
effective rate was 3.4%.Adverse drug reactions:only some subjects in narrowband
group experienced mild erythema，pigmentation and
pruititis. But adverse drug reaction rate in modified PUVA group was 40.3%，most
of them were mild or moderate gastrointestinal reactions，pruititis
and pigmentation etc.Radiation duration.The longest time was not longer than
7 minutes for narrowband group，but
it was up to 30 minutes for modified PUVA group subjects.
Conclusion
Narrowband UVB has favorable
effect for vulgar chronic plaque psoriasis.Though narrowband
UVB is a little less effective than modified PUVA method，it
is simple to conduct，having no need to take drugs，with
short radiation time and lower incidence of adverse reactions.
Key
words：
Modified PUVA method；Narrowband
UVB；Psoriasis
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